ANGPTL4
angiopoietin-like 4
Sinónimos:
ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, UNQ171, pp1158
Especie:
Human ANGPTL4 (51129), Mouse Angptl4 (57875), Rat Angptl4 (362850), naked mole-rat Angptl4 (101718658), domestic guinea pig Angptl4 (100733453), Goat ANGPTL4 (100860916), sheep ANGPTL4 (101104317), Zebrafish angptl4 (492647), domestic cat ANGPTL4 (101090747), cow ANGPTL4 (509963) ...Más
ID UniProtKB:
ID del gen:
- Human(51129) Summary: This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4. [provided by RefSeq, Jul 2008]
- Mouse(57875) angiopoietin-like 4
- Rat(362850) angiopoietin-like 4
- naked mole-rat(101718658) angiopoietin-like 4
- domestic guinea pig(100733453) angiopoietin-like 4
- Goat(100860916) angiopoietin-like 4
- sheep(101104317) angiopoietin-like 4
- Zebrafish(492647) angiopoietin-like 4
- domestic cat(101090747) angiopoietin-like 4
- cow(509963) angiopoietin-like 4
- dog(476724) angiopoietin-like 4
- chicken(769087) angiopoietin-like 4
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