ACO1
aconitase 1, soluble
Sinónimos:
ACONS, IREB1, IREBP, IREBP1, IRP1
Especie:
Human ACO1 (48), Mouse Aco1 (11428), Rat Aco1 (50655), Zebrafish aco1 (568448), cow ACO1 (512995), Horse ACO1 (100067866), domestic cat ACO1 (101095526), dog ACO1 (481576), chicken ACO1 (373916), Thale Cress ACO1 (816478) ...Más
ID UniProtKB:
ID del gen:
- Human(48) Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- Mouse(11428) aconitase 1
- Rat(50655) aconitase 1, soluble
- Zebrafish(568448) aconitase 1, soluble
- cow(512995) aconitase 1, soluble
- Horse(100067866) aconitase 1, soluble
- domestic cat(101095526) aconitase 1, soluble
- dog(481576) aconitase 1, soluble
- chicken(373916) aconitase 1, soluble
- Thale Cress(816478) 1-aminocyclopropane-1-carboxylate oxidase 1
- Thale Cress(829737) aconitate hydratase 1
- domestic guinea pig(100720793) aconitase 1, soluble
- naked mole-rat(101716545) aconitase 1, soluble
- sheep(101112791) aconitase 1, soluble
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Reactividad de especies
human, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Reactividad de especies
human
Aplicación
immunohistochemistry