- The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of
The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of
Frontiers in microbiology (2017-05-26)
Fang Xie, Yalei Wang, Gang Li, Shuanghong Liu, Ning Cui, Siguo Liu, Paul R Langford, Chunlai Wang
PMID28539918
ABSTRACT
Antimicrobial peptides are essential to the innate immune defense of the mammal against bacterial infection. However, pathogenic bacteria have evolved multiple strategies to resist and evade antimicrobial peptides, which is vital to bacterial survival and colonization in hosts. PR-39 is a linear porcine antimicrobial peptide containing 39 amino acid residues with a high proline content. Resistance to antimicrobial peptide PR-39 has been observed in