- Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.
Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand.
Chemical communications (Cambridge, England) (2013-08-21)
Pierre Murat, Michael V Gormally, Debbie Sanders, Marco Di Antonio, Shankar Balasubramanian
PMID23949446
ABSTRACT
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
MATERIALS