- FXR agonist activity of conformationally constrained analogs of GW 4064.
FXR agonist activity of conformationally constrained analogs of GW 4064.
Bioorganic & medicinal chemistry letters (2009-07-10)
Adwoa Akwabi-Ameyaw, Jonathan Y Bass, Richard D Caldwell, Justin A Caravella, Lihong Chen, Katrina L Creech, David N Deaton, Kevin P Madauss, Harry B Marr, Robert B McFadyen, Aaron B Miller, Frank Navas, Derek J Parks, Paul K Spearing, Dan Todd, Shawn P Williams, G Bruce Wisely
PMID19586769
ABSTRACT
Two series of conformationally constrained analogs of the FXR agonist GW 4064 1 were prepared. Replacement of the metabolically labile stilbene with either benzothiophene or naphthalene rings led to the identification of potent full agonists 2a and 2g.
MATERIALS
Product Number
Brand
Product Description
SKU
Pack Size
Availability
Price
Quantity