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  • Lamotrigine in epilepsy, pregnancy and psychiatry--a drug for all seasons?

Lamotrigine in epilepsy, pregnancy and psychiatry--a drug for all seasons?

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (2012-10-06)
Frank J E Vajda, Seetal Dodd, David Horgan
ABSTRACT

Lamotrigine has been demonstrated to be effective as both an antiepileptic drug and a mood stabiliser. For epilepsy it is less efficacious than valproate in primary generalised epilepsy, but it is comparable to some traditional drugs in partial epilepsy. In psychiatry it has significant advantages over other mood stabilisers for the treatment and prevention of depressive phases of bipolar illness, but not for the treatment of mania. It has a more benign adverse effect profile than older antiepileptic agents and is not a proven teratogen. Risk of adverse reactions is reduced by commencing treatment at a markedly reduced dose that is gradually increased.

MATERIALS
Product Number
Brand
Product Description

Supelco
Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material
Sigma-Aldrich
Lamotrigine, ≥98%, powder
Lamotrigine, European Pharmacopoeia (EP) Reference Standard
USP
Lamotrigine, United States Pharmacopeia (USP) Reference Standard
Lamotrigine for system suitability, European Pharmacopoeia (EP) Reference Standard
Lamotrigine for peak identification, European Pharmacopoeia (EP) Reference Standard