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EMU090681

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Xrn1

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGGGAAAGGCAGTCTTTGTTAACTGGCCTCATCTTGAAGAAGCTAGAGTTGTGGCAGTATCAGATGGTGAAACTAAGTTTTACATAGAAGAACCTCCAGGAACACAGAAGGTTTATTTGGGAAAAACTGCCCCACCATCTAAAGTCATCCAACTTACAGATAAAGAACAATCGAACTGGACTAAAGAAATACAAGGAATTTCAGAACAATATCTAAGAAGAAAGGGAATAATAATAAATGAAACATCTGCTGTTGTGTATGCTCAGTTGCTCACGGGTCGTAAATATCAAATCAGTCAGAATGGTGAAGTTCGTCTAGAAAAACAGTGGTCAAAACAAATTCTTCCTTTTGTTTATCAAACTATTGTTAAGGACATCCGAGCTTTTGACTCTCGTTTCTCCAATATCAAGACATTGGATGACTTGTTTCCACCGAGAACTATGGTCTTTATGCTTGGAACTCCTTATTATGGCTGCACTGGAGAAGTTCAGGATTCAGGAGACTTGATTACAGAAGGGAGAATTCGTGTGGTTTTCAGCATTCCATGTGAGCCAAATCTTGATGC

Ensembl | mouse accession no.

ENSMUSG00000032410

NCBI accession no.

NM_011916

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... XRN1(24127) , Xrn1(24127)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Shin-Ichiro Hori et al.
Biochemical and biophysical research communications, 464(2), 506-511 (2015-07-15)
Antisense oligonucleotides (ASOs) can suppress the expression of a target gene by cleaving pre-mRNA and/or mature mRNA via RNase H1. Following the initial endonucleolytic cleavage by RNase H1, the target RNAs are degraded by a mechanism that is poorly understood.
Oussama Meziane et al.
Scientific reports, 5, 16688-16688 (2015-11-21)
The decapping scavenger enzyme DcpS is known for its role in hydrolyzing the cap structure following mRNA degradation. Recently, we discovered a new function in miRNA degradation activation for the ortholog of DcpS in C. elegans. Here we show that

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