E-060

17β-Estradiol solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₈H₂₄O₂
• CAS Number: 50-28-2
• Molecular Weight: 272.38
• MDL number: MFCD00003693
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798978

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in acetonitrile
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing; clinical testing
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: CC12CCC3C(CCc4cc(O)ccc34)C1CCC2O
• InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
• InChI key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• Gene Information: human ... ESR1(2099)

Description

General description

A Certified Spiking Solution^® suitable for use as starting material in calibrators, controls, or linearity standards for a variety of LC/MS or GC/MS applications from endocrinology to clinical and diagnostic testing.

17β-Estradiol belongs to the group of endogenous endocrine disruptors that disturb thyroid activity and function. It is also a sex hormone prescribed under the trade names Vagifem^®, Estring^®, Evamist, Elestrin^®, Estrace^®, and Estrogel^® as a treatment for hypoestrogenism.

Application

The Certified Reference Material (CRM) in solution can also be used as follows:

• Electrochemical determination of 17β-Estradiol in river water samples using a reduced graphene oxide and a metal complex porphyrin-based sensor
• Development of a fluorescence resonance energy transfer (FRET) based aptasensor to determine 17β-Estradiol in environmental water, urine, and milk samples
• Analysis of milk product samples to estimate 17β-Estradiol by high-performance liquid chromatography (HPLC) coupled with fluorescence detection following its solid phase extraction using graphene/multi-walled carbon nanotubes (MWCNTs)
• Solid phase extraction of 17β-estradiol and 17α-ethinylestradiol from tap water samples using magnetic graphene oxide (GO)/γ-Fe₂O₃ nanoparticles for their simultaneous quantification by high-performance liquid chromatography (HPLC) combined with fluorescence detector
• Multi-residue analysis of 17β-estradiol and 17α-ethinylestradiol in commercial pharmaceutical formulation and urine samples using hanging mercury drop electrode and screen printed carbon electrode

Features and Benefits

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Elestrin is a registered trademark of Azur Pharma

Estrace is a registered trademark of Warner Chilcott Company, LLC

Estring is a registered trademark of Pfizer Health AB

Estrogel is a registered trademark of Ascend Therapeutics, Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Vagifem is a registered trademark of Novo Nordisk A/S Corp.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H302 + H312 + H332 - H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2 °C - closed cup