TYROBP
TYRO protein tyrosine kinase binding protein
Synonyms:
DAP12, KARAP, PLOSL
Species:
Human TYROBP (7305), Mouse Tyrobp (22177), Rat Tyrobp (361537), Zebrafish tyrobp (100101461), domestic cat TYROBP (101082964), dog TYROBP (476477), cow TYROBP (282390), sheep TYROBP (443208), naked mole-rat Tyrobp (101707522), domestic guinea pig Tyrobp (100726186)
UniProtKB ID:
Gene ID:
- Human(7305) Summary: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
- Mouse(22177) TYRO protein tyrosine kinase binding protein
- Rat(361537) Tyro protein tyrosine kinase binding protein
- Zebrafish(100101461) TYRO protein tyrosine kinase binding protein
- domestic cat(101082964) TYRO protein tyrosine kinase binding protein
- dog(476477) TYRO protein tyrosine kinase binding protein
- cow(282390) TYRO protein tyrosine kinase binding protein
- sheep(443208) TYRO protein tyrosine kinase binding protein
- naked mole-rat(101707522) TYRO protein tyrosine kinase binding protein
- domestic guinea pig(100726186) TYRO protein tyrosine kinase binding protein
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TYROBP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species