PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
Synonyms:
PDHA, PDHCE1A, PHE1A
Species:
Human PDHA1 (5160), Mouse Pdha1 (18597), Rat Pdha1 (29554), chicken PDHA1 (418610), domestic cat PDHA1 (101080765), dog PDHA1 (480858), cow PDHA1 (407109), sheep PDHA1 (101110118), domestic guinea pig Pdha1 (100735725), naked mole-rat Pdha1 (101716937)
UniProtKB ID:
Gene ID:
- Human(5160) Summary: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
- Mouse(18597) pyruvate dehydrogenase E1 alpha 1
- Rat(29554) pyruvate dehydrogenase (lipoamide) alpha 1
- chicken(418610) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic cat(101080765) pyruvate dehydrogenase (lipoamide) alpha 1
- dog(480858) pyruvate dehydrogenase (lipoamide) alpha 1
- cow(407109) pyruvate dehydrogenase (lipoamide) alpha 1
- sheep(101110118) pyruvate dehydrogenase (lipoamide) alpha 1
- domestic guinea pig(100735725) pyruvate dehydrogenase (lipoamide) alpha 1
- naked mole-rat(101716937) pyruvate dehydrogenase (lipoamide) alpha 1
- Domestic Rabbit(100357349) pyruvate dehydrogenase (lipoamide) alpha 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PDHA1 Antibody, clone 1B13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, human, monkey, mouse, porcine, rat
Application
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-PDHA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-PDHA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PDHA1 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-p-PDHA1-Ser232 Antibody, clone 2D5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, horse, human, monkey, mouse, rat, sheep
Application
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Kits
Product Number
Description
Species
Pyruvate Dehydrogenase Activity Assay Kit, sufficient for 100 colorimetric tests,
Species
rat, mouse, human