IL12RB2
interleukin 12 receptor, beta 2
Synonyms:
Species:
Human IL12RB2 (3595), Mouse Il12rb2 (16162), Rat Il12rb2 (171334), domestic guinea pig Il12rb2 (100722774), naked mole-rat Il12rb2 (101717608), sheep IL12RB2 (100820736), Domestic Rabbit IL12RB2 (100350416), Zebrafish il12rb2 (100134971), cow IL12RB2 (282452), domestic cat IL12RB2 (101088012) ...More
UniProtKB ID:
Gene ID:
- Human(3595) Summary: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(16162) interleukin 12 receptor, beta 2
- Rat(171334) interleukin 12 receptor, beta 2
- domestic guinea pig(100722774) interleukin 12 receptor, beta 2
- naked mole-rat(101717608) interleukin 12 receptor, beta 2
- sheep(100820736) interleukin 12 receptor, beta 2
- Domestic Rabbit(100350416) interleukin 12 receptor, beta 2
- Zebrafish(100134971) interleukin 12 receptor, beta 2a
- cow(282452) interleukin 12 receptor, beta 2
- domestic cat(101088012) interleukin 12 receptor, beta 2
- dog(489550) interleukin 12 receptor, beta 2
- chicken(424705) interleukin 12 receptor, beta 2
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