CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
Synonyms:
CP2B, CYP1, CYP1alpha, CYP27B, P450c1, PDDR, VDD1, VDDR, VDDRI, VDR
Species:
Human CYP27B1 (1594), Mouse Cyp27b1 (13115), Rat Cyp27b1 (114700), domestic cat CYP27B1 (100750221), dog CYP27B1 (481133), Horse CYP27B1 (100034100), cow CYP27B1 (539630)
UniProtKB ID:
Gene ID:
- Human(1594) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]
- Mouse(13115) cytochrome P450, family 27, subfamily b, polypeptide 1
- Rat(114700) cytochrome P450, family 27, subfamily b, polypeptide 1
- domestic cat(100750221) cytochrome P450, family 27, subfamily B, polypeptide 1
- dog(481133) cytochrome P450, family 27, subfamily B, polypeptide 1
- Horse(100034100) cytochrome P450, family 27, subfamily B, polypeptide 1
- cow(539630) cytochrome P450, family 27, subfamily B, polypeptide 1
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