ALPL
alkaline phosphatase, liver/bone/kidney
Synonyms:
AP-TNAP, APTNAP, HOPS, TNAP, TNSALP
Species:
Human ALPL (249), Mouse Alpl (11647), Rat Alpl (25586), Zebrafish alpl (393982), domestic cat ALPL (727689), dog ALPL (403548), chicken ALPL (396317), cow ALPL (280994), naked mole-rat Alpl (101725910), domestic guinea pig Alpl (100718683)
UniProtKB ID:
Gene ID:
- Human(249) Summary: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
- Mouse(11647) alkaline phosphatase, liver/bone/kidney
- Rat(25586) alkaline phosphatase, liver/bone/kidney
- Zebrafish(393982) alkaline phosphatase, liver/bone/kidney
- domestic cat(727689) alkaline phosphatase, liver/bone/kidney
- dog(403548) alkaline phosphatase, liver/bone/kidney
- chicken(396317) alkaline phosphatase, liver/bone/kidney
- cow(280994) alkaline phosphatase, liver/bone/kidney
- naked mole-rat(101725910) alkaline phosphatase, liver/bone/kidney
- domestic guinea pig(100718683) alkaline phosphatase, liver/bone/kidney
- sheep(101123195) alkaline phosphatase, liver/bone/kidney
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ALPL antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-ALPL antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Monoclonal ANTI-FLAG® M2-Alkaline Phosphatase antibody produced in mouse, clone M2, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
all
Application
ELISA
Anti-Alkaline Phosphatase (ALPL) antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Kits
Product Number
Description
Species