Developing Sustainable Synthetic Methods

WEBINAR

The Fujiwara–Moritani reaction has had a profound contribution in the emergence of contemporary C–H activation protocols. But the associated reactivity and regioselectivity issues had rendered it redundant. The revival of this exemplary reaction often requires high thermal energy to promote olefination and leads to multiple site functionalizations. In this webinar, learn how we mitigated these factors to establish:

• A photoredox catalytic system constituting a merger of palladium/organo-photocatalyst (PC) that forges oxidative olefination in an explicit regioselective fashion with diverse arenes and heteroarenes.
  
• Visible light plays a significant role in executing “regioresolved” Fujiwara–Moritani reactions without the requirement of silver salts and thermal energy.
  
• The catalytic system is also amenable toward proximal and distal olefination aided by the respective directing groups (DGs), which entails the versatility of the protocol in engaging the entire spectrum of C(sp2)–H olefination.
  
• Furthermore, streamlining the synthesis of natural products, chiral molecules, drugs, and diversification through late-stage functionalizations underscore the importance of this sustainable protocol.
  
• The photoinduced attainment of this regioselective transformation is mechanistically established through control reactions and kinetic studies.

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