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LC/MS Analysis of CYP2D6 Inhibitors on Ascentis® Express HILIC

LC/MS Analysis of CYP2D6 Inhibitors on Ascentis® Express HILIC application for HPLC

Materials

mobile phase component

Product No.
Description
Pricing

70221

Ammonium formate

eluent additive for LC-MS, LiChropur™, ≥99.0%

standard

Product No.
Description
Pricing

1500218

Paroxetine hydrochloride

United States Pharmacopeia (USP) Reference Standard

PHR1384

Amitriptyline hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

PHR1394

Fluoxetine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

CONDITIONS

column

Ascentis Express HILlC, 10 cm x 2.1 mm I.D., 2.7 μm particles (53939-U)

mobile phase

5 mM ammonium formate in 2:98 (v/v) water:acetonitrile

flow rate

1.2 mL/min

column temp.

50 °C

detector

ESI(+), m/z 100-400

injection

0.5 μL

Description

Analysis Note

This application demonstrates the suitability of the Ascentis Express HILIC for the analysis of CYP2D6 Inhibitors.

Legal Information

Ascentis is a registered trademark of Merck KGaA, Darmstadt, Germany

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