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Merck

Diagnosis and management of infantile hemangiomas.

Pediatric clinics of North America (2014-03-19)
Katherine B Püttgen
ABSTRACT

Propranolol has replaced corticosteroids as preferred first-line therapy for the management of infantile hemangiomas (IH). The topical β-blocker timolol is now an alternative to oral propranolol and watchful waiting for smaller IH. Research in the last decade has provided evidence-based data about natural history, epidemiology, and syndromes associated with IH. The most pressing issue for the clinician treating children with IH is to understand current data to develop an individualized risk stratification for each patient and determine the likelihood of complications and need for treatment. This article emphasizes the nuances of complicated clinical presentations and current treatment recommendations.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
(±)-Propranolol hydrochloride, ≥99% (TLC), powder
Supelco
Propranolol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
Propranolol hydrochloride, European Pharmacopoeia (EP) Reference Standard
USP
Propranolol hydrochloride, United States Pharmacopeia (USP) Reference Standard
Supelco
(±)-Propranolol hydrochloride, analytical standard
Supelco
Propranolol hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®