- Permeability of the mitochondrial outer membrane to organic cations.
Permeability of the mitochondrial outer membrane to organic cations.
Biochimica et biophysica acta (1989-06-06)
C A Mannella, Q Wang
PMID2730913
ABSTRACT
Inhibition of mitochondrial respiration by hydrophobic fluorescent dyes (Rhodamine 6G, Safranine O, Pyronine B) is much less potentiated by digitonin-lysis of the outer membrane than that by polyamines or adriamycin. This situation may be explained by impermeability of the anion-selective channels in the outer mitochondrial membrane to large cations and by the ability of hydrophobic (but not polar or amphipathic) ions to directly permeate lipid bilayers.
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