- Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.
Chemical modification of erythromycins. IV. Synthesis and biological properties of 6-O-methylerythromycin B.
The Journal of antibiotics (1990-05-01)
S Morimoto, T Adachi, Y Misawa, T Nagate, Y Watanabe, S Omura
PMID2358406
ABSTRACT
6-O-Methylerythromycin B has been synthesized from erythromycin B via regioselective methylation of the 6-hydroxyl group in 71% overall yield. This compound shows in vitro antibacterial activity comparable to erythromycins A and B and exhibits superior in vivo activity with improved pharmacokinetic properties.
MATERIALS
Product Number
Brand
Product Description
Erythromycin B, European Pharmacopoeia (EP) Reference Standard