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  • Subventricular zone in motor neuron disease with frontotemporal dementia.

Subventricular zone in motor neuron disease with frontotemporal dementia.

Neuroscience letters (2011-05-28)
Lucia Galan, Ulises Gomez-Pinedo, Alvaro Vela-Souto, Antonio Guerrero-Sola, Juan Antonio Barcia, Alberto Rábano Gutierrez, Armando Martinez-Martinez, Maria Sagrario Barquero Jiménez, Jose Manuel García-Verdugo, Jorge Matias-Guiu
PMID21616125
ABSTRACT

Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS.