Tangential Flow Filtration Devices
From single-use to multi-use, our tangential flow filtration (TFF) products are ideal for pharma and biopharma manufacturing.
![Single-pass TFF with Pellicon® 3 cassettes Pellicon® single-pass TFF is a convenient way to reduce volumes to eliminate tank bottlenecks, reduce the size of subsequent steps, concentrate with inline buffer addition for desalting, and facilitate high final concentrations with high product recovery](/deepweb/assets/sigmaaldrich/marketing/global/images/categories/pharma-and-biopharma-manufacturing/single-pass-tiff-with-pellicon-3-cassettes/single-pass-tiff-with-pellicon-3-cassettes.jpg)
Pellicon® Single-Pass TFF
Single-pass TFF with our Pellicon® capsules and cassettes streamlines processing by concentrating process streams without the recirculation of traditional TFF. This is a simple way to increase capacity, concentration, and product recovery while improving footprint. This versatile application also enables continuous and intensified processing, in which in-line volume reduction is coupled to other process steps.
![Pellicon® Capsules for single-use tangential flow filtration Our single-use Pellicon® Capsules can be ready to perform ultrafiltration and diafiltration of mAbs and ADCs in minutes](/deepweb/assets/sigmaaldrich/marketing/global/images/categories/pharma-and-biopharma-manufacturing/pellicon-capsules-single-use-tangential-flow-filtration/pellicon-capsules-single-use-tangential-flow-filtration.jpg)
Pellicon® Capsules
Pellicon® Capsules with Ultracel® membrane are designed for streamlined ultrafiltration and diafiltration of biopharmaceuticals, offering ease of use and process flexibility. This innovative capsule is a true single-use TFF device with a unique plug-and-play, holderless design that comes ready to process in minutes.
![Pellicon® 3 cassettes Pellicon® 3 cassettes deliver high protein yield with consistent purity and quality for a variety of drug products](/deepweb/assets/sigmaaldrich/marketing/global/images/categories/pharma-and-biopharma-manufacturing/pellicon-3-cassettes/pellicon-3-cassettes.jpg)
Pellicon® 3 Cassettes
Pellicon® 3 cassettes deliver high protein yield and consistent performance while offering broad chemical compatibility. They are available with Ultracel® and Biomax® membranes for different processing needs, including mAbs, plasma, insulin, peptides, and vaccines. To overcome high viscosity challenges, our Pellicon® 3 cassettes with D screen are optimized to achieve higher protein concentrations.
Pellicon® 2 Cassettes
Pellicon® 2 cassettes are ideal for the ultrafiltration and diafiltration of biologics including concentration, desalting, and buffer exchange of polysaccharides, virus suspensions, and protein solutions. Our Ultracel® and Biomax® membranes offer efficient ultrafiltration while Durapore® membrane is best suited for microfiltration.
Pellicon® XL 50 Cassettes
Pellicon® XL 50 cassettes couple our ultrafiltration and microfiltration membranes with linear scalability for process development or small-volume processing.
Prostak™ Microfiltration Modules
Prostak™ microfiltration modules provide robust construction, reliable performance, and steam-in-place capability, making them suitable for clarification, cell harvest, and multi-use perfusion. The low hold-up volume and open channel design allow high product recovery and gentle flow path for processing shear-sensitive materials.
Support for Qualification, Risk Assessment, and Process Optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Articles
- /technical-documents/technical-article/pharmaceutical-and-biopharmaceutical-manufacturing/downstream-processing/tangential-flow-filtration-downstream-bioprocessing
- /technical-documents/technical-article/pharmaceutical-and-biopharmaceutical-manufacturing/downstream-processing/tangential-flow-filtration-antibody-drug-conjugate-manufacturing
- /technical-documents/technical-article/pharmaceutical-and-biopharmaceutical-manufacturing/downstream-processing/single-pass-tangential-flow-filtration-implementation-scaling
Related Product Resources
mAb Expression, Purification, and Formulation
Single-use Product Specifications
Data Sheet: Pellicon® Capsules with Ultracel® Membrane
Multi-use Product Specifications
Data Sheet: Pellicon® 3 Cassettes with Ultracel® Membrane
Data Sheet: Pellicon® 3 Cassettes with Biomax® Membrane
Data Sheet: Pellicon® 2 Filters and Holders
Data Sheet: Prostak™ Microfiltration Modules
Data Sheet: Pellicon® XL 50 Cassettes
General Product Specifications
Data Sheet: Pellicon® Single-Pass Tangential Flow Filtration
Data Sheet: Ultracel® Membranes
Data Sheet: Biomax® Membranes
Single-use Operations
Performance Guide: Pellicon® Capsules with Ultracel® Membrane Performance Guide
Application Note: Pellicon® Capsules for Single-use Tangential Flow Filtration
Application Note: Pellicon® Capsules for Ultrafiltration/Diafiltration in the Antibody Drug Conjugate Manufacturing Process
Article: ADC Review: Trial of High Efficiency TFF Capsule Prototype for ADC Purification
Article: European Biopharmaceutical Review: Novel TFF Capsule Evaluation
Multi-use Operations
Performance Guide: Pellicon® 3 Cassettes with Ultracel® Membrane Performance Guide
Performance Guide: Pellicon® 3 Cassettes with Biomax® Membrane Performance Guide
Application Note: Performance Evaluation and Cleanability Study using Pellicon® 3 Cassettes with 30 kD Biomax® and Ultracel® Ultrafiltration Membranes
Application Note: Pellicon® 3 Cassettes with High Viscosity Feed Screen
Intensified Operations
Application Note: Process Optimization and Scalability Evaluation of Pellicon® Capsules for Single-pass Tangential Flow Filtration of mAb-Based Biomolecules
Article: Adding Versatility with Single-Pass TFF
White Paper: Streamlining Bioprocessing Using Pellicon® Cassettes for Single-pass Operation
To continue reading please sign in or create an account.
Don't Have An Account?