P9389
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt
double stranded, alternating copolymer
Synonym(s):
Poly(dG-dC) • Poly(dG-dC)
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About This Item
General description
Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.
Application
Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
- in electrophoretic mobility shift assay of transcription factor IIIB complex
- as synthetic copolymers for circular dichroism (CD) spectroscopy studies
- as a positive control in liquid scintillation counting
Other Notes
Alternating copolymer; self-complementary, form double-stranded complex
Unit Definition
One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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