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P3635

Sigma-Aldrich

5β-Pregnane-3α,20α-diol glucuronide

≥98.00% (TLC), powder, progesterone metabolite

Synonym(s):

P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide

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About This Item

Empirical Formula (Hill Notation):
C27H44O8
CAS Number:
1852-49-9
Molecular Weight:
496.63
MDL number:
MFCD00056522
UNSPSC Code:
51111800
PubChem Substance ID:
24898430
NACRES:
NA.77

product name

5β-Pregnane-3α,20α-diol glucuronide,

sterility

non-sterile

Assay

≥98.00% (TLC)

form

powder

technique(s)

enzyme immunoassay: suitable

solubility

ethanol: 20 mg/mL, clear, colorless

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O

InChI

1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)

InChI key

ZFFFJLDTCLJDHL-UHFFFAOYSA-N

General description

5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.

Application

5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Susanna J Park et al.
Fertility and sterility, 88(3), 684-690 (2007-04-17)
To define characteristics of the luteinizing hormone (LH) surge in urine. Observational study. Academic center. 46 women aged 20 to 35 years with regular menstrual cycles. Collected first morning urine daily, throughout one menstrual cycle. Urinary LH, follicle-stimulating hormone (FSH)
Janine Volkery et al.
Berliner und Munchener tierarztliche Wochenschrift, 123(11-12), 500-505 (2010-12-15)
The objective of the present study was the measurement of the pregnancy associated hormones progesterone (P4) and pregnanediol-glucuronide (PdG) in saliva, milk and urine of alpacas and their potential use in pregnancy diagnosis. Sample of blood, saliva, milk and urine
Aaryn C Mustoe et al.
American journal of primatology, 74(11), 1044-1053 (2012-08-07)
Endocrine data and characteristics of nonconceptive ovarian cycling and pregnancy are limited within the genus Callithrix to the common marmoset (C. jacchus) and Wied's black tufted-ear marmoset (C. kuhlii). This article presents patterns of urinary pregnanediol-3-glucuronide (PdG) excretion, as determined
Jennifer E Mersereau et al.
Menopause (New York, N.Y.), 15(3), 482-486 (2008-01-19)
To compare daily reproductive hormone secretion in regularly menstruating older versus younger women. This was a prospective cohort study. Daily morning urine samples were obtained from 106 women, 28 of whom were aged between 20 and 34 years (mean: 27.8+/-3.7
Kathleen A O'Connor et al.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 18(3), 828-836 (2009-02-26)
Detailed characterization of estrogen dynamics during the transition to menopause is an important step toward understanding its potential implications for reproductive cancers developing in the transition years. We conducted a 5-year prospective study of endogenous levels of total and unopposed
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