A2691
Anti-Human IgA (α-chain specific)−Agarose antibody produced in goat
affinity isolated antibody, adsorbed with mouse and rat IgG
Synonym(s):
Goat Anti-Human IgA
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About This Item
Recommended Products
biological source
goat
Quality Level
conjugate
agarose conjugate
antibody form
affinity isolated antibody
antibody product type
secondary antibodies
clone
polyclonal
form
PBS suspension
species reactivity
human
should not react with
rat, mouse
capacity
3-4 mg/mL binding capacity (human IgA)
storage temp.
2-8°C
target post-translational modification
unmodified
General description
Binding Capacity: One mL of antibody binds 3-4 mg human IgA. Elution Capacity is 2-4 mg/mL.
IgA antibody plays an essential role in mucosal immunity. It has shown to bind immunogens/pathogens to restrict them from entering the mucosal membrane. The Anti-Human IgA (α-chain specific) product increases sensitivity to human IgA without cross-reactivity to other substances. Offering minimal interspecies cross reactivity to mouse or a rat, making it ideal for use in screening antibodies produced by a hybridoma cells containing a mouse or a rat immunoglobulins.
Immunogen
IgA produced from transformed cell line of human Epstein-Barr virus.
Application
Affinity chromatography using anti-human IgA antibody linked to agarose was performed to purify proteins from 2E9IgA1 transfectant cells.
Anti-Human IgA (α-chain specific)-Agarose antibody produced in goat has been used in affinity chromatography and quantitative enzyme linked immunosorbent assay (ELISA).
Physical form
Suspension in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Susanne Wolbank et al.
Journal of virology, 77(7), 4095-4103 (2003-03-14)
We have previously generated human monoclonal anti-human immunodeficiency virus type 1 (anti-HIV-1) antibodies 2F5IgG and 2G12IgG with an exceptional cross-clade neutralizing potential. 2F5IgG and 2G12IgG passively administrated to macaques were able to confer complete protection from both intravenous and mucosal
Poor ex vivo induction of T-cell responses to idiotype or tumor cell lysate-pulsed autologous dendritic cells in advanced pre-treated multiple myeloma
Garderet L, et al.
Leukemia & Lymphoma, 47(7), 1340-1347 (2006)
Suckow MA, et al.
The Laboratory Rat (2005)
Y J Wen et al.
Blood, 97(6), 1750-1755 (2001-03-10)
Multiple myeloma (MM) is a B-cell malignancy. The monoclonal immunoglobulin, secreted by myeloma plasma cells, carries unique antigenic determinants (idiotype [Id]) that can be regarded as a tumor-specific antigen. Id-based immunotherapy has been explored in myeloma patients for the purpose
J Berdoz et al.
Proceedings of the National Academy of Sciences of the United States of America, 96(6), 3029-3034 (1999-03-17)
The hallmark of a mucosal immune response is the production of antigen-specific secretory IgA (S-IgA) antibodies in external secretions. S-IgA consists of ten polypeptides produced in two different cell lineages. The heavy and light chains in plasma cells assemble into
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