901990

Tetrazine-acid

• Synonym(s): 4-(1,2,4,5-Tetrazin-3-yl)benzeneacetic acid
• Empirical Formula (Hill Notation): C₁₀H₈N₄O₂
• CAS Number: 1380500-92-4
• Molecular Weight: 216.20
• MDL number: MFCD24503098
• UNSPSC Code: 12352106
• NACRES: NA.22

Properties

• form: powder or crystals
• availability: available only in USA
• storage temp.: −20°C

Description

Application

Tetrazine-acid demonstrates exceptionally fast cycloaddition kinetics with trans-cyclooctene (TCO) as the dienophile (up to 30,000 M^-1 s^-1). These have been the fastest kinetics reported for a bio orthogonal reaction. The chemical stability of tetrazines is substantially lower compared to methyltetrazines, thus requiring more careful selection of reagents and conditions for chemical transformation. However, tetrazine chemistry is still in an acceptable range for many applications.

Safety Information

• Pictograms: GHS02
• Signal Word: Danger
• Hazard Statements: H242
• Precautionary Statements: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class Code: 5.2 - Organic peroxides and self-reacting hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable