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Merck

PTGER4

prostaglandin E receptor 4 (subtype EP4)

Synonyms:
EP4, EP4R
Species:
UniProtKB ID:
Gene ID:
  • Human(5734) Summary: The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
  • Mouse(19219) prostaglandin E receptor 4 (subtype EP4)
  • Rat(84023) prostaglandin E receptor 4 (subtype EP4)
  • domestic guinea pig(100192398) prostaglandin E receptor 4 (subtype EP4)
  • Domestic Rabbit(100009081) prostaglandin E receptor 4 (subtype EP4)
  • naked mole-rat(101723705) prostaglandin E receptor 4 (subtype EP4)
  • cow(282331) prostaglandin E receptor 4 (subtype EP4)
  • sheep(101104343) prostaglandin E receptor 4 (subtype EP4)
  • sheep(443222) prostaglandin E receptor 4 (subtype EP4)
  • chicken(427183) prostaglandin E receptor 4 (subtype EP4)
  • domestic cat(101094734) prostaglandin E receptor 4 (subtype EP4)
  • domestic cat(100169968) prostaglandin E receptor 4 (subtype EP4)
  • dog(403589) prostaglandin E receptor 4 (subtype EP4)

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
Dinoprostone, United States Pharmacopeia (USP) Reference Standard,
Species
human
Dinoprostone, European Pharmacopoeia (EP) Reference Standard,
Species
human
Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, ≥98% (HPLC), synthetic,
Species
human, mouse

Small Molecule - Antagonist

Product Number
Description
Species
Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse
Prostaglandin E1, ≥98% (HPLC), synthetic,
Species
human, mouse
Prostaglandin E2, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse
Prostaglandin E2, synthetic, powder, BioReagent, suitable for cell culture,
Species
human, mouse

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-EP4 Prostaglandin Receptor antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
canine, human
Application
ELISA
western blot
Anti-PTGER4 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-PE2R4 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
Prostaglandin E2, ≥93% (HPLC), synthetic,
Species
mouse, human
Indomethacin, 98.5-100.5% (in accordance with EP),
Species
human, mouse, rat

Proteins

Product Number
Description
Species
ChemiScreen Membrane Preparation
Recombinant Human EP4 Prostanoid Receptor
, Human EP4 GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PTGER4,
Species
human
MISSION® esiRNA, targeting mouse Ptger4,
Species
mouse