- Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.
Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.
Brain research (2008-06-21)
Ahmet H Kaya, Rinske Vlamings, Sonny Tan, Lee Wei Lim, Peter J Magill, Harry W M Steinbusch, Veerle Visser-Vandewalle, Trevor Sharp, Yasin Temel
PMID18565496
ABSTRACT
Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.