Spasmolytic Activity of Carvone and Limonene Enantiomers.

Spasmolytic Activity of Carvone and Limonene Enantiomers.

Natural product communications (2016-01-12)

Damião Pergentino de Sousa, Rafael Ferreira Mesquita, Luciano Augusto de Araújo Ribeiro, Julianeli Tolentino de Lima

ABSTRACT

Aromatic plants produce volatile substances with high therapeutic potential. In view of the need for new respiratory and cardiovascular system pharmacological agents, the present study reports on the spasmolytic activity of two enantiomers of carvone and limonene, constituents of essential oils. The enantiomers tested showed pharmacological activity in Guinea pig trachea and rat aorta smooth muscle. No differences were observed in the pharmacological profiles of the enantiomer pairs. The oxygenated monoterpenes (+)-carvone and (-)-carvone were pharmacologically more effective than the hydrocarbon monoterpenes (+)-limonene and (-)-limonene. The results of this study show the therapeutic potential of these compounds found in many aromatic plants for the treatment of respiratory and cardiovascular system diseases.

MATERIALS

Product Number

Brand

Product Description

401676

Sigma-Aldrich

Sodium hydrogencarbonate, −40-+140 mesh, ≥95%

P4504

Sigma-Aldrich

Potassium chloride, ReagentPlus^®, ≥99.0%

S6014

Sigma-Aldrich

Sodium bicarbonate, ACS reagent, ≥99.7%

793590

Sigma-Aldrich

Potassium chloride, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99%

900506

Sigma-Aldrich

Sodium bicarbonate, anhydrous, free-flowing, Redi-Dri^™, ReagentPlus^®, ≥99.5%

60130

Sigma-Aldrich

Potassium chloride, puriss. p.a., ≥99.5% (AT)

13433

Sigma-Aldrich

Sodium bicarbonate, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

12636

Sigma-Aldrich

Potassium chloride, puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E508, 99-100.5% (AT), ≤0.0001% Al

P3911

Sigma-Aldrich

Potassium chloride, ACS reagent, 99.0-100.5%

792519

Sigma-Aldrich

Sodium bicarbonate, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥99.7%

P9333

Sigma-Aldrich

Potassium chloride, BioXtra, ≥99.0%

P9541

Sigma-Aldrich

Potassium chloride, for molecular biology, ≥99.0%

S6297

Sigma-Aldrich

Sodium bicarbonate, BioXtra, 99.5-100.5%

P5405

Sigma-Aldrich

Potassium chloride, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99.0%

P9327

Sigma-Aldrich

Potassium chloride solution, 0.075 M, sterile-filtered, BioXtra, suitable for cell culture

60128

Sigma-Aldrich

Potassium chloride, BioUltra, for molecular biology, ≥99.5% (AT)

60142

Sigma-Aldrich

Potassium chloride solution, BioUltra, for molecular biology, ~1 M in H₂O

S5761

Sigma-Aldrich

Sodium bicarbonate, powder, BioReagent, for molecular biology, suitable for cell culture, suitable for insect cell culture

204099

Sigma-Aldrich

Potassium chloride, ≥99.99% trace metals basis

449989

Sigma-Aldrich

Potassium chloride, AnhydroBeads^™, −10 mesh, 99.999% trace metals basis

451029

Sigma-Aldrich

Potassium chloride, AnhydroBeads^™, −10 mesh, 99.99% trace metals basis

409316

Sigma-Aldrich

Potassium chloride, 99.999% trace metals basis

S0817

Sigma-Aldrich

Sodium chloride solution, 0.85%

S6191

Sigma-Aldrich

Sodium chloride, BioPerformance Certified, ≥99% (titration), suitable for insect cell culture, suitable for plant cell culture

59222C

SAFC

Sodium chloride solution, 5 M

W224908

Sigma-Aldrich

L-Carvone, natural, 99%, FG

63140

Sigma-Aldrich

Magnesium sulfate heptahydrate, puriss. p.a., ACS reagent, ≥99.0% (KT)

M1880

Sigma-Aldrich

Magnesium sulfate heptahydrate, ReagentPlus^®, ≥99.0%

13142

Sigma-Aldrich

Magnesium sulfate heptahydrate, 99.5-100.5% (calc. to the dried substance), meets analytical specification of Ph. Eur., BP,USP, FCC

230391

Sigma-Aldrich

Magnesium sulfate heptahydrate, ACS reagent, ≥98%