- Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Bioorganic & medicinal chemistry letters (2009-03-24)
Yuli Xie, Yidong Liu, Gangli Gong, Deborah H Smith, Fang Yan, Alison Rinderspacher, Yan Feng, Zhengxiang Zhu, Xiangpo Li, Shi-Xian Deng, Lars Branden, Dusica Vidović, Caty Chung, Stephan Schürer, Christophe Morisseau, Bruce D Hammock, Donald W Landry
PMID19303288
ABSTRACT
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.
MATERIALS