- Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia.
Efficacy of sulfamethoxypyridazine in a murine model of Pneumocystis carinii pneumonia.
Antimicrobial agents and chemotherapy (1998-04-29)
M S Bartlett, M M Shaw, J W Smith, S R Meshnick
PMID9559812
ABSTRACT
Sulfamethoxazole is the component of co-trimoxazole responsible for its efficacy against Pneumocystis carinii pneumonia, but this drug is associated with frequent adverse effects. Sulfamethoxypyridazine is significantly more effective than sulfamethoxazole against a murine model of P. carinii and might be a candidate for testing in infected patients.
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