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632732

Sigma-Aldrich

1-Boc-pyrazole-4-boronic acid pinacol ester

97%

Synonym(s):

1,1-dimethylethyl ester 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-Pyrazole-1-carboxylic acid, 1-tert-Butoxycarbonyl-4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrazole, 1-Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole, 1-Boc-4-pyrazoleboronic acid pinacol ester, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-Boc-pyrazole, 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylic acid tert-butyl ester, tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-pyrazolecarboxylate, [1-(tert-Butoxycarbonyl)-1H-pyrazol-4-yl]boronic acid pinacol ester

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About This Item

Empirical Formula (Hill Notation):
C14H23BN2O4
Molecular Weight:
294.15
MDL number:
MFCD05663873
UNSPSC Code:
12352103
PubChem Substance ID:
24882509
NACRES:
NA.22

Assay

97%

form

solid

mp

82-86 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(C)(C)OC(=O)n1cc(cn1)B2OC(C)(C)C(C)(C)O2

InChI

1S/C14H23BN2O4/c1-12(2,3)19-11(18)17-9-10(8-16-17)15-20-13(4,5)14(6,7)21-15/h8-9H,1-7H3

InChI key

IPISOFJLWYBCAV-UHFFFAOYSA-N

Application

Reagent used for
  • Suzuki Coupling
  • Copper-catalyzed azidation

Reagent used in Preparation of
  • Selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
  • Stereoselective synthesis of selective Cathepsin inhibitors

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Copper(II)-catalyzed conversion of aryl/heteroaryl boronic acids, boronates, and trifluoroborates into the corresponding azides: substrate scope and limitations
K. D. Grimes, et al.,
Synthesis, 9, 1441-1448 (2010)
John J Caldwell et al.
Journal of medicinal chemistry, 54(2), 580-590 (2010-12-29)
Structure-based design was applied to the optimization of a series of 2-(quinazolin-2-yl)phenols to generate potent and selective ATP-competitive inhibitors of the DNA damage response signaling enzyme checkpoint kinase 2 (CHK2). Structure-activity relationships for multiple substituent positions were optimized separately and
Paul A Bethel et al.
Bioorganic & medicinal chemistry letters, 19(16), 4622-4625 (2009-07-21)
A number of molecular recognition features have been exploited in structure-based design of selective Cathepsin inhibitors.

Articles

Suzuki–Miyaura Coupling Reagents

This brochure contains a comprehensive selection of boronic acids, boronic acid esters, diboron esters, and transition-metal catalysts useful for the Suzuki–Miyaura coupling reaction

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