CD209
CD209 molecule
Synonyms:
CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Species:
Human CD209 (30835), Zebrafish cd209 (100334918), cow CD209 (513266), domestic cat CD209 (100462978), dog CD209 (485000)
UniProtKB ID:
Gene ID:
- Human(30835) Summary: This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
- Zebrafish(100334918) CD209 molecule
- cow(513266) CD209 molecule
- domestic cat(100462978) CD209 molecule
- dog(485000) CD209 molecule
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CD209 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
western blot
Anti-CD209 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
Monoclonal Anti-CD209-APC antibody produced in mouse, clone UW60.1,
Species Reactivity
Application
flow cytometry
Anti-CD209 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-DC-SIGN [8B6] antibody produced in mouse, affinity purified immunoglobulin (IgG),
Species Reactivity
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species