- Failure to Inactivate Nuclear GSK3β by Ser
Failure to Inactivate Nuclear GSK3β by Ser
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2017-08-24)
Tina M Thornton, Brendan Hare, Sandra Colié, William W Pendlebury, Angel R Nebreda, William Falls, Diane M Jaworski, Mercedes Rincon
PMID28832021
초록
GSK3β plays an essential role in promoting cell death and is emerging as a potential target for neurological diseases. Understanding the mechanisms that control neuronal GSK3β is critical. A ubiquitous mechanism to repress GSK3β involves Akt-mediated phosphorylation of Ser