Diclofenac sodium ion exchange resin complex loaded melt cast films for sustained release ocular delivery.

The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFS Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFS Complexation efficiency of DFS:IR was found to be 99% with a 1:1 ratio of DFS:IR. DFS release from DFS:IR suspension and the film were best-fit to a Higuchi model. In vitro transcorneal flux with the DFS DFS