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  • Breast cancer stem cells: eradication by differentiation therapy?

Breast cancer stem cells: eradication by differentiation therapy?

Cell (2009-08-26)
Hartmut Beug
초록

During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.

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Sigma-Aldrich
Salinomycin, Ready Made Solution, from Streptomyces albus, ≥98% (HPLC)