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Merck
  • Synthesis of the eastern portion of ajudazol a based on Stille coupling and double acetylene carbocupration.

Synthesis of the eastern portion of ajudazol a based on Stille coupling and double acetylene carbocupration.

Organic letters (2005-03-12)
Oliver Krebs, Richard J K Taylor
초록

[structure: see text] A strategy for the synthesis of ajudazol A, an unusual, pharmacologically active metabolite from myxobacteria, based on the Stille cross-coupling of a 2-stannyl-oxazole with a vinyl iodide unit is described; the vinyl halide unit containing a (Z,Z)-diene was prepared in one pot by the double acetylene carbocupration of a functionalized alkyl cuprate followed by trapping with 2,3-dibromopropene.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
2-(Tri-n-butylstannyl)oxazole