- Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.
Stereoselective allosteric binding interaction on human serum albumin between ibuprofen and lorazepam acetate.
Chirality (1999-02-10)
I Fitos, J Visy, M Simonyi, J Hermansson
PMID9951402
초록
The effect of ibuprofen enantiomers on the stereoselective binding of 3-acyloxy-1,4-benzodiazepines to human serum albumin (HSA) was studied using both native and Sepharose-immobilized protein. (S)-Lorazepam acetate exhibited considerably enhanced binding, especially in the presence of (+)-(S)-ibuprofen. The phenomenon is an indication of cooperative allosteric interaction between different binding sites during multiple cobinding of two ligands.
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