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Merck

Epimerization of benzylpenicilloic acid in alkaline media.

Journal of pharmaceutical sciences (1984-01-01)
I Ghebre-Sellassie, S L Hem, A M Knevel
초록

5R,6R-Benzylpenicilloic acid was found to epimerize slowly in alkaline media to 5S,6R-benzylpenicilloic acid until equilibrium was established. Epimerization proceeded via the imine tautomer of penamaldic acid rather than the enamine form and was found to favor the 5S,6R-epimer at equilibrium. The conversion process was monitored using both reverse-phase high-performance liquid chromatography and NMR spectroscopy.

MATERIALS
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Sigma-Aldrich
Benzylpenicilloic acid disodium salt, mixture of epimeres, ≥95% (HPLC)