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Merck
  • The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations.

The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations.

Pharmaceutical development and technology (2009-10-22)
Antonella Casiraghi, Paola Minghetti, Francesco Cilurzo, Francesca Selmin, Veniero Gambaro, Luisa Montanari
초록

This work aimed to evaluate the effect induced by excipients conventionally used for topical dosage forms, namely isopropyl myristate (IPM) or oleic acid (OA) or polyethylene glycol 400 (PEG400) or Transcutol (TR), on the human skin permeability of terpinen-4-ol (T4OL) contained in the pure Tea tree oil. The effect of such excipients was determined by evaluating the absorption of T4OL using human epidermis and the perturbation of the organization of stratum corneum by ATR-FTIR. Among the tested excipients OA enhanced the absorption of T4OL by perturbing the stratum corneum lipid barrier. Other excipients caused a weak enhancement effect and their use should be carefully monitored.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
4-Carvomenthenol, natural, ≥95%, FG
Sigma-Aldrich
4-Carvomenthenol, ≥95%, FCC, FG
Terpinen 4-ol, primary reference standard