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Merck
  • A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene .

A new synthesis of Rink's polymer, 4-(2',4'-dimethoxyphenylhydroxymethyl)phenoxymethylpolystyrene .

International journal of peptide and protein research (1994-01-01)
G Váradi, G K Tóth, B Penke
초록

For solid-phase peptide synthesis, 2,4-dimethoxy-4'-hydroxbenzhydrol linker was prepared via lithium borohydride reduction of 2,4-dimethoxy-4'-hydroxybenozophenone. The potassium salt of the linker was coupled to chloromethylpolystyrene. This method proved to be better than use of the cesium salt. This new synthesis gave a polymer with appropriate structure and a good degree of substitution.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Lithium borohydride, ≥95.0%
Sigma-Aldrich
Lithium borohydride, ≥90%
Sigma-Aldrich
Lithium borohydride, hydrogen-storage grade, ≥90%
Sigma-Aldrich
Lithium borohydride solution, 2.0 M in THF
Sigma-Aldrich
Lithium borohydride solution, 0.5 M in diethyl ether