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Merck
  • The role of electrostatic interactions in modulating the local anaesthetic effects of amphipathic agents in frog skeletal muscle.

The role of electrostatic interactions in modulating the local anaesthetic effects of amphipathic agents in frog skeletal muscle.

Canadian journal of physiology and pharmacology (1984-04-01)
J G Foulks, L Morishita
초록

The local anaesthetic effect of cationic, anionic, and neutral alkyl amphipathic agents was similarly enhanced in an apparently nonspecific way by circumstances which modulate electrostatic interactions (acidity, modification of charged groups at the sarcolemmal surface by group-specific reagents, or changes in the calcium concentration), presumably as the result of secondary effects on the conformation of membrane proteins. However, the selective enhancement of the local anaesthetic effect of alkyl trimethylammonium compounds by perchlorate implies a more specific interaction which may influence the penetration of hydrophobic groups into the membrane interior.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Trimethyloctylammonium bromide, ≥98.0% (AT)
Sigma-Aldrich
Trimethyloctylammonium chloride, ≥97.0% (AT)