- Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols.
Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols.
Molecules (Basel, Switzerland) (2011-11-25)
Dayvson J Palmeira, Juliana C Abreu, Leandro H Andrade
PMID22113578
초록
Lipase-catalyzed kinetic resolution of aryltrimethylsilyl chiral alcohols through a transesterification reaction was studied. The optimal conditions found for the kinetic resolution of m- and p-aryltrimethylsilyl chiral alcohols, led to excellent results, high conversions (c = 50%), high enantiomeric ratios (E > 200) and enantiomeric excesses for the remaining (S)-alcohol and (R)-acetylated product (>99%). However, kinetic resolution of o-aryltrimethylsilyl chiral alcohols did not occur under the same conditions applied to the other isomers.
MATERIALS
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브랜드
제품 설명
Sigma-Aldrich
Celite® 545 AW, filter aid, acid washed, treated with sodium carbonate, flux calcined