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Merck
  • BOP-mediated one-pot synthesis of C5-symmetric macrocyclic pyridone pentamers.

BOP-mediated one-pot synthesis of C5-symmetric macrocyclic pyridone pentamers.

Chemical communications (Cambridge, England) (2011-10-22)
Zhiyun Du, Changliang Ren, Ruijuan Ye, Jie Shen, Victor Maurizot, Yujin Lu, Jian Wang, Huaqiang Zeng
초록

We report here, for the first time, the BOP-mediated one-pot macrocyclization that is facilitated and guided by internally placed intramolecular H-bonds to allow for the highly selective formation of five-residue cation-binding macrocycles.

MATERIALS
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Sigma-Aldrich
(Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 97%