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  • Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.

Copper-catalyzed asymmetric addition of arylboronates to isatins: a catalytic cycle involving alkoxocopper intermediates.

Chemical communications (Cambridge, England) (2010-08-21)
Ryo Shintani, Keishi Takatsu, Tamio Hayashi
초록

A copper-catalyzed addition of arylboronates to isatins has been developed to give 3-aryl-3-hydroxy-2-oxindoles under mild conditions. The catalytic cycle of this process has been examined through a series of stoichiometric reactions and an effective asymmetric variant has also been described by the use of a chiral N-heterocyclic carbene ligand.

MATERIALS
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브랜드
제품 설명

Sigma-Aldrich
2-Oxindole, 97%