- Reinvestigation of the synthesis of 1-deazauridine.
Reinvestigation of the synthesis of 1-deazauridine.
Nucleosides, nucleotides & nucleic acids (2010-07-01)
Cheng-Hung Jen, Tun-Cheng Chien
PMID20589571
초록
A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(beta-D-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved.
MATERIALS