- Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.
Study on glycosylated prodrugs of toxoflavins for antibody-directed enzyme tumor therapy.
Carbohydrate research (2007-04-07)
Shusheng Wang, Dan Liu, Xu Zhang, Shengyu Li, Yongxu Sun, Jia Li, Yifa Zhou, Liping Zhang
PMID17412311
초록
Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by (13)C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against beta-glucosidase (EC.3.2.1.21).
MATERIALS