- Extracellular superoxide dismutase and cardiovascular disease.
Extracellular superoxide dismutase and cardiovascular disease.
Cardiovascular research (2002-07-19)
Tohru Fukai, Rodney J Folz, Ulf Landmesser, David G Harrison
PMID12123763
초록
Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O(2)(*-)), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O(2)(*-) are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.
MATERIALS
제품 번호
브랜드
제품 설명
Sigma-Aldrich
Superoxide Dismutase bovine, recombinant, expressed in E. coli, lyophilized powder, ≥2500 units/mg protein, ≥90% (SDS-PAGE)