- New probes of the agonist binding site of metabotropic glutamate receptors.
New probes of the agonist binding site of metabotropic glutamate receptors.
Bioorganic & medicinal chemistry letters (2001-06-20)
A S Bessis, J Bolte, J P Pin, F Acher
PMID11412983
초록
The (2S,4R)- and (2S,4S)-4-hydroxyglutamates activate cloned mGlu(1a), mGlu(2), and mGlu(8a) receptors with different potencies. Best results were obtained with the (2S,4S) isomer being almost as potent as glutamate on mGlu(1a)R and mGlu(8a)R. Data are interpreted on the basis of the binding site model and X-ray structure.
MATERIALS