콘텐츠로 건너뛰기
Merck
  • Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.

Nystatin induces secretion of interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha by a toll-like receptor-dependent mechanism.

Antimicrobial agents and chemotherapy (2005-07-29)
Raymund R Razonable, Martin Henault, Harold L Watson, Carlos V Paya
초록

Nystatin is an antifungal compound with potent proinflammatory properties. Herein, we demonstrate that nystatin induces interleukin (IL)-1beta, IL-8, and tumor necrosis factor alpha secretion through its activation of toll-like receptor 1 (TLR1) and TLR2. Hence, a TLR-dependent mechanism could serve as the molecular basis for the proinflammatory properties of nystatin.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Nystatin, ≥4,400 USP units/mg