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Merck
모든 사진(1)

주요 문서

U0881

Sigma-Aldrich

Uric acid

BioXtra, ≥99% (HPLC)

동의어(들):

2,6,8-Trihydroxypurine

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About This Item

실험식(Hill 표기법):
C5H4N4O3
CAS Number:
Molecular Weight:
168.11
Beilstein:
156158
EC Number:
MDL number:
UNSPSC 코드:
12352005
PubChem Substance ID:
NACRES:
NA.55

생물학적 소스

animal (seabird feces (guano))

Quality Level

제품 라인

BioXtra

분석

≥99% (HPLC)

양식

powder

불순물

≤0.005% Phosphorus (P)

무기 잔류물

≤0.1%

mp

>300 °C (lit.)

solubility

1 M NaOH: soluble 50 mg/mL, clear, faintly yellow

양이온 미량물

Al: ≤0.005%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.05%
Mg: ≤0.001%
NH4+: ≤0.05%
Na: ≤0.1%
Pb: ≤0.001%
Zn: ≤0.0005%

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일반 설명

Uric acid is the terminal product of purine degradation in humans. It is formed from the action of xanthine oxidase upon xanthine. Elevated levels of uric acid may clinically be manifested as gout. In species other than humans, uric acid can be further metabolized. In mammals other than primates, uric acid is converted to allantoin. In teleost fish, allantoin is further converted to allantoate, which is hydrolyzed to urea and glyoxylate. Uric acid may also be used in the biosynthesis of purines. It has been studied as a scavenger of biological free radicals like peroxynitrite. High-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) methods for uric acid have been published. Uric acid promotes monocyte chemoattractant protein-1 (MCP-1) expression in vascular smooth muscle cells.

애플리케이션

Uric acid has been used:
  • to prepare monosodium urate (MSU) crystals to study its effect on nuclear localization leucine-rich-repeat protein 1 (NLRP1) gene expression
  • as a reductant to test its protective potential against met-myoglobin formation
  • to prepare MSU to study its use as specific ligand of Clec12a.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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문서 라이브러리 방문

John Kanellis et al.
Hypertension (Dallas, Tex. : 1979), 41(6), 1287-1293 (2003-05-14)
Previous studies have reported that uric acid stimulates vascular smooth muscle cell (VSMC) proliferation in vitro. We hypothesized that uric acid may also have direct proinflammatory effects on VSMCs. Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte
Waleed Al Abdulmonem et al.
Protein and peptide letters, 28(3), 282-289 (2020-09-23)
Myoglobin is an oxygen binding protein and its dysfunction has been associated with the pathology of several human disorders. This study was undertaken to investigation the role of hydrogen peroxide (H2O2) in the formation of met-myoglobin and the protective potential
Francesca Viazzi et al.
Pediatrics, 132(1), e93-e99 (2013-06-19)
Hyperuricemia has been shown to be a strong correlate of hypertension in children. However, the complex interaction between serum uric acid (UA), systemic blood pressure (BP), and possibly confounding factors has been elucidated only in part. We evaluated office BP
S F Seys et al.
Allergy, 70(2), 187-194 (2014-11-02)
Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite
Tom M Palmer et al.
BMJ (Clinical research ed.), 347, f4262-f4262 (2013-07-23)
To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as

문서

Uric acid is not a direct additive to any of the classical cell culture media. However, it is present in animal sera. Consequently, uric acid is typically present in complete serum-supplemented classical cell culture systems.

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