T4827

Trandolapril

≥98% (HPLC), white, powder

• 동의어(들): (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid, Mavik
• 실험식(Hill 표기법): C₂₄H₃₄N₂O₅
• CAS Number: 87679-37-6
• Molecular Weight: 430.54
• MDL number: MFCD00865776
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329826801
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white
• solubility: DMSO: ≥20 mg/mL
• 주관자: Abbott
• SMILES string: CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2C3CCCCC3C[C@H]2C(O)=O
• InChI: 1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21-/m0/s1
• InChI key: VXFJYXUZANRPDJ-WTNASJBWSA-N
• 유전자 정보: human ... ACE(1636)

설명

애플리케이션

Trandolapril has been used as an angiotensin-converting enzyme (ACE) inhibitor to study its effects on responsiveness of human retinal endothelial cells (HRECs) to vascular endothelial growth factor (VEGF).

생화학적/생리학적 작용

Studies have reported that trandolapril inhibits atherosclerosis¹ and decreases the occurrence of atrial fibrillation².

Trandolapril is an ACE inhibitor. Trandolapril differs from other ACE inhibitors in that it has a longer biological half-life and a high degree of lipophilicity.

특징 및 장점

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Trandolapril is soluble in DMSO at a concentration that is greater than or equal to 20 mg/ml.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360D
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)